منابع مشابه
Chemical structure and the changing concept of vitamin A activity.
Studies on chemical structure and vitamin activity have an archaic tang, redolent of the pioneering days of vitamin research, and interest in them has long waned for most vitamins. Vitamin A is an exception, partly because its molecular mode of action (apart from in the visual pigments) is uncertain, but largely because the concept of vitamin A activity has not remained static. The traditional ...
متن کاملVitamin K Activity and Structure
This paper presents the results of assays for antihemorrhagic activity carried out on an array of naphthoquinones and related compounds synthesized as described in a series of previous papers. Some of the compounds were prepared as synthetic models of the structural types postulat.ed (1) for vitamins K1 and Kz (l-5); others were synthesized subsequent to the establishment of the structure of vi...
متن کاملA QUANTUM CHEMICAL STUDY OF STRUCTURE -ACTIVITY RELATIONSHIPS OF DIHYDROPYRIDINE CALCIUM ANTAGONISTS
Quantum chemical (MNDo)caleulations have beenused toelucidate the molecular properties and structure - activity relationships of dihydropyridine (DHP) type calcium antagonists. There is a good corielation between the net atomic charges on various atoms of the 4 - phenyl ring of dihydropyridines and pharmacological activity. .Also, activity decreases with increasing free rotation of the phen...
متن کاملRelationship between Inhibitory Activity and Chemical Structure
When it was found tha t 2,5-dimethylbenzimidazole inhibits the multiplication of influenza viruses (1-3), a systematic investigation of other alkyl derivatives of benzimidazole was undertaken. I t seemed probable tha t studies on the relationship between the chemical structure of such derivatives and their inhibitory act ivi ty relative to influenza virus multiplication would yield information ...
متن کاملChemical structure and immunobiological activity of Porphyromonas gingivalis lipid A.
In 1933, Boivin et al. extracted an endotoxin from Salmonella typhimurium for the first time, after which a variety of chemical and biological studies on endotoxins have been performed. In 1952, the structural and functional properties of endotoxic lipopolysaccharide (LPS), extracted by a hot phenol and water method devised by Westphal et al., were reported, which led to a number of studies of ...
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ژورنال
عنوان ژورنال: Proceedings of the Nutrition Society
سال: 1965
ISSN: 0029-6651,1475-2719
DOI: 10.1079/pns19650028